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. 2021 Oct 27;11:21221. doi: 10.1038/s41598-021-98949-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Baicalein and baicalin exhibited virucidal activity against DENV-3 progeny in a dose-dependent manner. Inhibition of viral progeny infectivity by baicalein was determined by (a) FFURA and (b) quantification of RNA copy number. Inhibition of viral progeny infectivity by baicalin was determined by (c) FFURA and (d) quantification of RNA copy number. Data presented as mean ± SEM. Error bars indicate the range of values obtained from three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 indicates a significant difference compared to the negative control analyzed by the t-test.