Figure 3.

SITDL simulations with and without stabilization mechanisms, under different sets of initial conditions. Each curve shows the changes in τ_Glu over time, for a single simulation with the specific initial τ_D value indicated by the color of the curve. (A) Changes in τ_Glu when starting with τ_Glu = 5 ms and different initial τ_D value for each curve, ranging from 1 to 17 ms. By 600,000 ms simulation time, each curve appears to reach more stable values. (B) Changes in τ_Glu with initial conditions τ_Glu = 5 ms and τ_D value ranging from 18 to 45 ms. In most cases, τ_Glu increases, but there does not appear to be sufficient simulation time for it to reach more stable values as in (A). (C) Changes in τ_Glu with initial conditions τ_Glu = 5 ms and τ_D value ranging from 46 to 100 ms, which provide much less overlap of glutamate and voltage signals. Certain τ_D values, such as 49 to 60 ms, 70 to 75 ms, and 90 to 100 ms, seem to provide sufficient overlap for τ_Glu to change significantly and potentially achieve coincidence of gate conductances with enough simulation time. (D–F) Same simulations and initial conditions as in Fig. 4A–C, but with stabilization mechanisms, which cause τ_Glu to stop changing when there is sufficient overall NMDAR conductance. Note, τ_Glu stabilization generally occurs more quickly for smaller τ_D, and even at high τ_D (18 to 100 ms), τ_Glu still stabilizes for certain values at the end of the simulation, despite limited overlap of the periodic signals. (G–I) Same simulations with stability mechanisms as in Figure (D–F), except with initial τ_Glu = 50 ms.