Table 1.
SITDL model constants.
| Symbol | Description | Values (no units, unless indicated) |
|---|---|---|
| σN | Dispersion constant for SN | |
| αL | Exponential constant for SGlu | 10.0 |
| I0 | Constant current for ID | 0.01 |
| aV | Exponential constant for gV(t) | – 8.0 |
| bV | Exponential constant for gV(t) | 5.0 |
| aL | Decay factor constant for gL(t) | 0.999 |
| bL | Signal input factor for gL(t) | 0.065 |
| Δt | Simulation time step constant | 0.01 ms |
| τFast | Time constant for glutamate gate activation of fast NMDARs | 7.0 ms |
| τSlow | Time constant for glutamate gate activation of slow NMDARs | 50.0 ms |
| nTotal | Total number of NMDAR receptors | 50 receptors |
| γ | Constant for scaling the time step Δτ | 1.0 |
| Δτ | Time step for changing τGlu | 0.05 ms |
| VRest | Normalized resting potential | 0.0 |
| τR | Time constant for V(t) | 1.0 ms |
| kD | Constant for dendritic current contribution | 3.9 |
| kS | Constant for synaptic current contribution | 0.40 |
| τP | Time constant for determining how slowly σ(t) changes | 20.0 ms |
| ΔτMax | Maximum of ΔτGlu, used for modulating changes in σ(t) | 0.0125 ms |
| aP | Exponential constant for logistic function of σ(t) in P(t) | 0.30 |
| bP | Exponential constant for logistic function of σ(t) in P(t) | – 70.0 |
| δ | Threshold factor for synaptic elimination (for τD step = 8 ms and 2 ms, respectively) | 1.002, and 1.0215 |