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. 2021 Oct 14;12:754316. doi: 10.3389/fimmu.2021.754316

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Copyright © 2021 Scheurer, Kitt, Huber, Fundel-Clemens, Pflanz, Debatin and Strauss

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Type 2 immune induction by cotransplanted CD11b+CD11c+ MDSCs is required for GVHD prevention. Lethally irradiated B6.bm1 (H-2K^bm1) recipient mice were reconstituted with B6-dervied (H-2K^b) T-cell-depleted bone marrow (TCD-BM) and SCs either derived from B6 wild-type (WT) mice (H-2K^b) or STAT6^−/− mice (H-2K^b). B6-derived (H-2K^b) CD11b+CD11c+ MDSCs were cotransplanted at day of transplantation. (A) Survival and (B) GVHD scores were analyzed. Surviving animals/total animals treated are indicated in brackets. (C) Ten days after transplantation, serum cytokine concentrations of Th2- (IL-5) and Th1-associated (IFN-γ and TNF-α) cytokines were determined. (A) Data represent the mean value ± SEM. (B) Kaplan-Meier method and Log-rank test. (C) Mann-Whitney U test. ^* p ≤ 0.05; ^** p ≤ 0.01; n.s., not significant.