Table 1.
GO term analysis and identification of biological and functional processes activated in CD11b+CD11c+ MDSCs compared with CD11b+CD11c− MDSCs.
| Biological and functional category | GO term | GO ID | p-value changed | FDR q-value | Number of target genes |
|---|---|---|---|---|---|
| Cell movement and migration | Cell motility | 0048870 | 2.50E−11 | 1.22E−07 | 62 |
| Cell migration | 0016477 | 4.54E−11 | 1.47E−07 | 59 | |
| Locomotion | 0040011 | 5.08E−11 | 1.23E−07 | 65 | |
| Lymphocyte migration | 0072676 | 1.51E−10 | 2.44E−07 | 12 | |
| Movement of cell or subcellular component | 0006928 | 2.87E−10 | 3.98E−07 | 70 | |
| Lymphocyte chemotaxis | 0048247 | 3.36E−09 | 3.63E−06 | 8 | |
| Chemotaxis | 0006935 | 1.46E−08 | 1.18E−05 | 28 | |
| Taxis | 0042330 | 3.04E−08 | 1.85E−05 | 28 | |
| Cell chemotaxis | 0060326 | 9.10E−08 | 4.92E−05 | 22 | |
| Monocyte chemotaxis | 0002548 | 1.23E−07 | 5.97E−05 | 8 | |
| Leukocyte chemotaxis | 0030595 | 1.61E−07 | 6.80E−05 | 12 | |
| Leukocyte migration | 0050900 | 2.36E−07 | 8.49E−05 | 21 | |
| Mononuclear cell migration | 0071674 | 8.46E−07 | 2.00E−04 | 9 | |
| Myeloid leukocyte migration | 0097529 | 3.72E−06 | 6.57E−04 | 10 | |
| Cell adhesion | Biological adhesion | 0022610 | 2.35E−08 | 1.53E−05 | 45 |
| Cell adhesion | 0007155 | 8.20E−08 | 4.69E−05 | 43 | |
| Positive regulation of cell-cell adhesion | 0022409 | 1.22E−07 | 6.26E−05 | 16 | |
| Positive regulation of cell adhesion | 0045785 | 9.26E−07 | 2.14E−04 | 19 | |
| Regulation of leukocyte cell-cell adhesion | 1903037 | 3.40E−06 | 6.62E−04 | 15 | |
| Regulation of cell-cell adhesion | 0022407 | 4.05E−06 | 7.02E−04 | 39 | |
| Leukocyte activation and immune response | Immune response | 0006955 | 1.47E−10 | 2.85E−07 | 55 |
| lymphocyte migration | 0072676 | 1.51E−10 | 2.44E−07 | 12 | |
| Positive regulation of immune system process | 0002684 | 1.25E−09 | 1.52E−06 | 60 | |
| Lymphocyte chemotaxis | 0048247 | 3.36E−09 | 3.63E−06 | 8 | |
| Monocyte chemotaxis | 0002548 | 1.23E−07 | 5.97E−05 | 8 | |
| Leukocyte chemotaxis | 0030595 | 1.61E−07 | 6.80E−05 | 12 | |
| positive regulation of lymphocyte activation | 0051251 | 1.77E−07 | 7.17E−05 | 31 | |
| Positive regulation of leukocyte activation | 0002696 | 1.84E−07 | 7.14E−05 | 34 | |
| Leukocyte migration | 0050900 | 2.36E−07 | 8.49E−05 | 21 | |
| Defense response | 0006952 | 2.79E−07 | 9.69E−05 | 55 | |
| Antigen processing and presentation of exogenous peptide antigen via MHC class II | 0019886 | 5.15E−07 | 1.43E−04 | 9 | |
| Antigen processing and presentation of peptide antigen via MHC class II | 0002495 | 5.15E−07 | 1.47E−04 | 9 | |
| Antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | 0002504 | 5.15E−07 | 1.52E−04 | 9 | |
| Positive regulation of leukocyte cell-cell adhesion | 1903039 | 5.40E−07 | 1.46E−04 | 14 | |
| Negative regulation of immune system process | 0002683 | 7.14E−07 | 1.78E−04 | 21 | |
| Positive regulation of T-cell activation | 0050870 | 8.39E−07 | 2.04E−04 | 13 | |
| Mononuclear cell migration | 0071674 | 8.46E−07 | 2.00E−04 | 9 | |
| Adaptive immune response | 0002250 | 1.40E−06 | 3.17E−04 | 12 | |
| Humoral immune response | 0006959 | 3.25E−06 | 6.45E−04 | 15 | |
| Regulation of leukocyte cell-cell adhesion | 1903037 | 3.40E−06 | 6.62E−04 | 15 | |
| Positive regulation of leukocyte differentiation | 1902107 | 3.58E−06 | 6.82E−04 | 23 | |
| Myeloid leukocyte migration | 0097529 | 3.72E−06 | 6.57E−04 | 10 | |
| Inflammatory response | 0006954 | 4.71E−06 | 7.89E−04 | 35 | |
| Regulation of leukocyte differentiation | 1902105 | 5.18E−06 | 8.53E−04 | 12 | |
| Antigen processing and presentation of exogenous peptide antigen | 0002478 | 6.45E−06 | 1.03E−03 | 9 | |
| Myeloid leukocyte migration | 0097529 | 3.72E−06 | 6.57E−04 | 10 | |
| ERK1 and ERK2 cascade | Regulation of ERK1 and ERK2 cascade | 0070372 | 3.59E−06 | 6.71E−04 | 16 |
| Positive regulation of ERK1 and ERK2 cascade | 0070374 | 2.31E−08 | 1.60E−05 | 16 | |
| Response to cytokine | Chemokine-mediated signaling pathway | 0070098 | 8.52E−09 | 7.53E−06 | 11 |
| Response to interferon-gamma | 0034341 | 2.09E−08 | 1.57E−05 | 20 | |
| Response to stress | Response to tumor necrosis factor | 0034612 | 1.94E−06 | 4.29E−04 | 9 |