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. 2021 Oct 14;11:719564. doi: 10.3389/fonc.2021.719564

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Copyright © 2021 Su, Lv, Lu, Yu, Ye, Guo, Liu, Yan, Li, Zhang, Cheng and Mo

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ligand–receptor interactions in RCC, prediction of drug target pathways and sensitivity to drug responses. (A) Ligand–receptor interactions in type 2 pRCC and CAFs. (B) Ligand–receptor interactions in ccRCC and CAFs. (C) Ligand–receptor interactions in type 2 pRCC and immune cells. (D) Spatial CAF location verified in type 2 pRCC using the CAF marker ACTA2 (green), epithelial cell marker KRT8 (red) and DNA staining via DAPI (blue) within the tissue paraffin sections from human type 2 pRCC samples. Scale bars, 50 μm. (E) Prediction of activation of drug target pathways. (F) Prediction of activation of drug sensitivity to drug responses. *p < 0.05, ***p < 0.01 and ****p < 0.001.