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Proposed model of TBM-1-mediated PD-L1 degradation by controlling mTOR-TFEB cascade to activate lysosome function. TBM-1 specific binds to and inactivates mTOR, which results in TFEB dephosphorylation and nuclear translocation, thus boosting lysosome biogenesis. Meanwhile, TBM-1 promotes PD-L1 translocation to lysosome, induces PD-L1 degradation and activation of tumor-infiltrating T cells.
