Table 1.
Patient | Age/sex | Stage/MIPI | IHC | IgH/CCND1 FISH | karyotype | outcome | ||||
---|---|---|---|---|---|---|---|---|---|---|
CD5 | CD20 | CD23 | Ciclina D1 | Ki-67% | ||||||
MCL#1 | 68/M | IVA | + | + | – | + | 10-15 | nd | nd | A |
MCL#2 | 66/F | IVA | + | + | – | + | nd | nd | nd | A |
MCL#3 | 70/M | IVB | + | + | + | nd | nd | nd | normal | D |
MCL#4 | 76/F | IVA/MIPI 5.9 (intermediate risk) | – | + | nd | + | nd | + | normal | A |
MCL#5 | 78/M | IVA | + | + | – | + | 40 | – | normal | D |
MCL#6 | 51/F | IVB/MIPI 6.6 (high risk) | – | nd | – | + | nd | – | normal | A |
MCL#7 | 74/M | IVA/MIPI 9 (high risk) | + | + | – | + | 40 | + | complex* | A |
MCL#8 | 81/F | IVA | + | + | – | + | nd | nd | normal | D |
MCL#9 | 81/M | IVA | + | ++ | – | + | nd | – | nd | D |
MCL#10 | 65/M | IVA/MIPI6.1 (intermediate risk) | + | – | – | + | 10 | – | normal | A |
MCL#11 | 55/F | IVA | + | ++ | – | + | nd | nd | nd | A |
MCL#12 | 74/F | IVA/MIPI 6.4 (high risk) | + | + | – | + | nd | + | Complex** | A |
MCL#13 | 72/F | IVA/MIPI 6.1 (intermediate risk) | + | + | – | + | nd | nd | complex*** | D |
MCL#14 | 71/M | nd | + | + | – | + | nd | + | complex**** | D |
MCL#15 | 85/F | IVA | + | + | – | + | nd | – | normal | D |
MCL#16 | 71/M | IVA/MIPI 6.1 (intermediate risk) | + | + | – | + | nd | + | normal | A |
MCL#17 | 79/M | IVA | + | ++ | + | + | nd | + | complex° | D |
MCL#18 | 68/M | IVB/MIPI high risk | + | ++ | – | + | nd | + | nd | A |
MCL#19 | 58/M | IVA/MIPI 5.6 (intermediate risk) | + | + | – | + | nd | + | complex°° | A |
MCL#20 | 61/M | IVA | + | + | – | + | nd | + | normal | A |
MIPI, Mantle cell International Prognostic Index; IHC, immunohistochemistry; nd, not determined; A, alive; D, death. M, male; F, female.
*43,XY,add(1)(q4)?,+3,del(6)(q13),-8,-9,der(10)t(10;13)(p13;q12),del(11)(q13),-13,-13,-14,+mar[13]/46,XY[12].ish add(1)(IGH++,CCND1++),der(11)t(11;14)(CCND1+,IGH+),add(?)(IGH+,CCND1+)[10].
**47XX,+3,del(6),t(10;15),t(11;14).
***62,XX,-X,-3,-5,+8,-12,-16,-17,dup(17)(p11p13),-18,+21,i(22)(q10),+mar[cp6]/46,XX[4].
****hyperdiploid karyotype due to a low number of mytosis with del(17)(p13) by FISH.
ᵒ42,X,-Y,+3,der(6;17)(q12;p11)?t(6;19)(q12;p13),i(8)(q10),der(11)t(11;14)(q13;q32),-13,-14,-15,add(15)(p13),add(20)(q13)[22]/46,XY[6].nuc ish(CCND1,IGH)x3(CCND1conIGHx2)[233/300].
ᵒᵒ43,C,-Y,+der(3)del(3)(p22)add(3)(q26),dic(4;6)(p16;q13),add(7)(p21),i(8)(q10),-10,t(11;14)(q13;q32),-13.der(15)t(10;15)(q21;q21),-20,-r[cp14]/46,XY[14].