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. 2021 Oct 14;15:738037. doi: 10.3389/fnins.2021.738037

FIGURE 2.

FIGURE 2

A concentric circular Manhattan plot of the GWAS results for smoking status (SS) and cigarette per day (CPD) for chromosomes 1–22. Each dot represents an SNV; x- and y-axis refer to genomic locations and –log10(p-value). The SNVs with –log10(p-value) are larger than 12 for chr15 and chr19 of CPD, and larger than 20 for chr9 and chr11 of SS were not included in the plot. The three highest signals mapped on genes CHRNB3, CHRNA3, CHRNB4, IREB2, CYP2A6, and RAB4B of CPD and the four highest signals mapped on genes FAM163B, SARDH, CNNM2, and NCAM1 and lncRNA LOC101928847 of SS are labeled in the plot. GWAS, genome-wide association study; CPD, cigarette per day; SNV, single-nucleotide variant.