Table 2.
Incidence of G3-4 neutropenia and febrile neutropenia according to risk factors
| Population N = 1155 | |||||||
|---|---|---|---|---|---|---|---|
| Risk factors | Number of patients | G3-4 neutropenia |
Febrile neutropenia |
||||
| Events, N (%) | OR (95% CI) | P | Events, N (%) | OR (95% CI) | P | ||
| Age | |||||||
| ≥65 years | 408 | 164 (40.2) | 1.37 (1.07-1.76) | 0.01 | 28 (6.86) | 1.24 (0.75-2.03) | 0.40 |
| <65 years | 747 | 246 (32.9) | 1 | 42 (5.62) | 1 | ||
| ECOG PS | |||||||
| 1-2 | 144 | 38 (26.4) | 0.62 (0.42-0.91) | 0.01 | 10 (6.9) | 1.18 (0.59-2.37) | 0.64 |
| 0 | 1011 | 372 (36.8) | 1 | 60 (5.9) | 1 | ||
| Sex | |||||||
| Female | 481 | 214 (44.5) | 1.95 (1.53-2.50) | <0.001 | 37 (7.7) | 1.62 (1.00-2.63) | 0.051 |
| Male | 674 | 196 (29.1) | 1 | 33 (4.9) | 1 | ||
| Bone metastasis | |||||||
| Yes | 39 | 9 (23.1) | 0.54 (0.25-1.14) | 0.10 | 5 (12) | 2.38 (0.90-6.28) | 0.08 |
| No | 1116 | 401 (35.9) | 1 | 65 (5.8) | 1 | ||
| Adjuvant chemotherapy | |||||||
| Yes | 79 | 36 (45.6) | 1.57 (0.99-2.49) | 0.054 | 3 (3.8) | 0.59 (0.18-1.93) | 0.39 |
| No | 1076 | 374 (34.8) | 1 | 67 (6.2) | 1 | ||
| Previous radiotherapy | |||||||
| Yes | 67 | 24 (35.8) | 1.02 (0.61-1.70) | 0.95 | 4 (6.0) | 0.98 (0.35-2.78) | 0.97 |
| No | 1088 | 386 (35.5) | 1 | 66 (6.1) | 1 | ||
Bold/italic are statistically significant P values.
CI, confidence interval; ECOG PS, Eastern Cooperative Group Performance Status; G, grade; N, number; OR, odds ratio.