FIGURE 5.

Jadomycin proposed mechanisms of action in breast cancer cells. (A) Some jadomycins are copper‐dependent and convert Cu(II) to Cu(I), leading to the production of ROS and subsequent DNA damage. ⁸ , ¹² (B) The DNA damage induced by jadomycins inhibits ABK and prevents mitosis and proliferation of breast cancer cells. ⁷ (C) Jadomycins B, S, and F have also demonstrated the ability to inhibit or poison topoisomerase II, which leads to further DNA damage and apoptosis. ⁷ Image created with BioRender.com