Table 2.
Geometric mean (GM) and percent coefficient of variation (%CV) of MPA PK parameter estimates by treatment group.
| 45mg | 75mg | 105mg | Depo-subQ 104 | |||||
| N | GM (%CV) | n | GM (%CV) | N | GM (%CV) | n | GM (%CV) | |
| Cmax | 15 | 0.40 (73.5) | 12 | 0.60 (68.1) | 15 | 0.87 (44.0) | 15 | 0.81 (48.0) |
| Tmax | 15 | 4.2 (152.2) | 12 | 4.9 (214.5) | 15 | 14.2 (128.2) | 15 | 16.7 (84.6) |
| C91 | 15 | 0.13 (41.9) | 10 | 0.23 (45.1) | 15 | 0.36 (50.9) | 15 | 0.39 (29.7) |
| C119 | 14 | 0.12 (48.8) | 10 | 0.21 (38.5) | 14 | 0.29 (43.7) | 13 | 0.31 (27.7) |
| AUC0–91 | 15 | 17.8 (37.1) | 11 | 26.0 (44.2) | 15 | 43.2 (29.3) | 15 | 44.6 (28.8) |
| AUC0–119 | 15 | 21.2 (35.2) | 11 | 32.6 (44.1) | 15 | 52.0 (29.1) | 15 | 54.5 (26.5) |
| AUC0-inf | 15 | 36.0 (26.8) | 10 | 59.8 (31.3) | 14 | 81.3 (30.4) | 15 | 99.6 (24.0) |
| Half-life | 15 | 72.9 (56.6) | 10 | 67.4 (75.6) | 14 | 47.1 (74.6) | 15 | 69.2 (71.3) |
AUC0-x , area under the concentration-time curve (days*ng/mL) from day 0 to day x; half-life (days); Cmax , maximum concentration; Tmax , time (days) of maximum concentration, Cx = concentration (ng/mL) at day x.