Table 3.
Baseline patient characteristics.
| Patient | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 |
| Treatment Dose | 100 x 106 | 100 x 106 | 100 x 106 | 200 x 106 | 200 x 106 | 200 x 106 | 400 x 106 | 400 x 106 | 400 x 106 |
| Gender | Female | Male | Male | Female | Male | Male | Male | Female | Male |
| Age (years) | 42 | 63 | 69 | 58 | 49 | 62 | 64 | 51 | 25 |
| Temperature (°C) | 38·1 | 37·5 | 36·1 | 36·2 | 36·7 | 40 | 36·4 | 39·2 | 37·7 |
| ARDS aetiology | Sepsis | Thoracic trauma Pneumonia |
Pneumonia Sepsis |
Aspiration Pneumonia Sepsis |
Aspiration | Pneumonia Sepsis |
Pneumonia Sepsis |
Pneumonia Sepsis |
Aspiration Pneumonia |
| APACHE II Score | 20 | 10 | 19 | 23 | 24 | 28 | 25 | 16 | 12 |
| Murray Lung Injury Score (LIS) | 2.5 | 2.0 | 1.5 | 2.8 | 3.8 | 2.8 | 2.3 | 3.0 | 2.3 |
| First Qualifying PaO2/FiO2 Ratio | 12·5 | 18·4 | 18·9 | 23·0 | 8·1 | 24·0 | 24·0 | 22·0 | 24·8 |
| Worst PaO2/FiO2 ratio ** | 12·5 | 28·3 | 24·3 | 12·5 | 8·0 | 17·7 | 24·0 | 17·2 | 22·4 |
| Total SOFA Score | 15·0 | 9·0 | – | 19·0 | 19·0 | 11·0 | 14·0 | 9·0 | 8·0 |
| Oxygenation Index (cmH2O/kPa) | 55·8 | – | 33·0 | 59·1 | 296·3 | 45·6 | 47·6 | 86·4 | 52·7 |
| Lowest Mean Arterial Pressure (mmHg) | 59·0 | 66·0 | 61·0 | 59·0 | 51·0 | 53·0 | 56·0 | 68·0 | 60·0 |
| PEEP (cmH2O) | 12·0 | 8·0 | 5·0 | 10·0 | 15·0 | 12·0 | 5·0 | 10·0 | 12·0 |
| Plateau Pressure (cmH2O) | 22·0 | – | 13·0 | 29·0 | 35·0 | 27·0 | 26·0 | 27·0 | 24·0 |
| Driving Pressure (cmH2O) | 10·0 | – | 8·0 | 19·0 | 20·0 | 15·0 | 21·0 | 17·0 | 12·0 |
| Mode of Ventilation | SIMV | PS | SIMV | SIMV | SIMV | SIMV | SIMV | SIMV | SIMV |
| Tidal Volume (ml/kg PBW) | 6·3 | 6·7 | 5·5 | 7·2 | 8·5 | 5·8 | 7·0 | 7·4 | 5·6 |
| Vital Status, Day of ICU Discharge or death | Alive, Day 24 | Alive, Day 9 | Alive, Day 9 | Dead, Day 7 | Dead, Day 14 | Dead, Day 9 | Dead, Day 8 | Alive, Day 25 | Alive, Day 11 |
*Patients may have > 1 aetiology of ARDS.
**Worst PF Ratio recorded on Day 0/24 h prior to randomisation.
ARDS = Acute Respiratory Distress Syndrome; APACHE = Acute Physiology and Chronic Health Evaluation; SOFA = Sequential Organ Failure Assessment; PEEP = Positive End Expiratory Pressure.