Table 4.

Linear regression model 1 using all genotypes to estimate the effects of APOE and covariates on cognitive function.

	Total cognition		Executive function		Language		Memory		Visuospatial cognition
Model	Coefficient	SE	Coefficient	SE	Coefficient	SE	Coefficient	SE	Coefficient	SE
All genotypes
ℇ3/ℇ4	−0.306	0.24	−0.042	0.10	−0.048	0.04	−0.062	0.06	−0.286*	0.14
ℇ3/ℇ2	−0.134	0.27	0.024	0.11	0.013	0.04	0.021	0.07	−0.063	0.16
ℇ2/ℇ4	−0.107	0.35	−0.025	0.15	−0.015	0.05	0.066	0.09	−0.060	0.22
ℇ4/ℇ4	0.114	0.39	−0.066	0.16	−0.058	0.06	−0.036	0.09	−0.164	0.24
ℇ2/ℇ2	0.434	0.57	0.489*	0.23	0.155	0.09	0.099	0.14	0.470	0.35
Age	−0.093***	0.01	−0.037***	<0.01	−0.013***	<0.01	−0.029***	<0.01	−0.081***	0.01
Male	−0.018	0.19	0.264*	0.08	0.059*	0.03	−0.05	0.05	0.383*	0.12
Education	1.758***	0.12	0.823***	0.05	0.355***	0.02	0.349***	0.03	1.394***	0.07
HIV positive	0.017	0.21	−0.004	0.09	−0.025	0.03	−0.041	0.05	−0.175	0.13
Adjusted R-squared	0.221	3.91	0.283	1.48	0.325	0.54	0.245	0.87	0.374	2.20

Standardised coefficients represent estimated changes in cognitive function. Domain estimates (executive function, language, memory, visuospatial cognition) change in standard deviation units. Adjusted R-squared values per model with residual standard error (SE) is shown.

^*p<0.05;

^**p<0.00001;

^***p<2e-16.