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. 2021 Oct 14;11:751086. doi: 10.3389/fonc.2021.751086

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Copyright © 2021 Yu, Gao, Wang, Xu, Maswikiti, Li, Zheng, Tao, Xiang, Gu, Lucas and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Potential applications of the lipids according to their various roles in cancer immunity. Three directions presented (yellow, blue, and purple nodes) for potential applications as summarized in the network diagram. The grey nodes in the last level indicate evidence types supporting each application. The adjacently spread nodes next to the last nodes represent lipids-related therapeutic targets or biomarkers. ACC, acetyl-CoA carboxylase; ACAT, acetyl-CoA acetyltransferase; BMI, body mass index; CAR-T, chimeric antigen receptor T cell; CPT1, carnitine palmitoyltransferase 1; FA, fatty acid; FAO, fatty acid oxidation; FASN, fatty acid synthase; FATP, transport protein; GD2, a disialoganglioside glycolipid; LMRG, lipid metabolism-related genes; PCSK9, proprotein convertase subtilisin/kexin type 9; PPAR, peroxisome proliferator-activated receptor; SCFAs, short-chain fatty acids; VLCFAs, very long-chain fatty acids.