Skip to main content
. 2021 Oct 14;12:750841. doi: 10.3389/fimmu.2021.750841

Figure 2.

Figure 2

GSDMD in nonhematopoietic cells is crucial for promoting DSS-induced injury. (A) During the progression of DSS-induced colitis, body weight change of the following BM-transplanted mice: WT → WT (n = 6), WT → Gsdmd-/- (n = 8), Gsdmd-/- → WT (n = 6), and Gsdmd-/- → Gsdmd-/- mice (n=7). (B) Bleeding score and stool score of the transplanted mice on Day 6 of the colitis model as in (A). (C, D) Colon length (C) and the macroscopic view (D) of the transplanted mouse colon on Day 8 of the colitis model as in (A). (E) H&E staining of the representative mouse colon on Day 8 of the colitis model as in (A) (200× magnification). Data are representative of two (A–E) independent experiments (mean ± SEM in A-C). *p < 0.05, **p < 0.01, ***p < 0.001 by Student’s t test.