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. 2021 Oct 14;12:729308. doi: 10.3389/fmicb.2021.729308

FIGURE 5.

FIGURE 5

GBS S protein is critical for GBS virulence in vitro and in vivo. (A) Whole blood survival assay results. Significance was determined using Tukey’s Multiple Comparisons Test (∗∗p < 0.01). (B) Neutrophil oxidative burst assay results. Significance was determined using Tukey’s Multiple Comparisons Test (*⁣*⁣**p < 0.0001). (C) Bacterial survival following incubation with primary human neutrophils. Significance was determined using Tukey’s Multiple Comparisons Test (∗∗p < 0.01; ∗∗∗p < 0.001). (D) Kaplan-Meier plot demonstrating survival after I.P. challenge with GBS strains. (E) Bacterial CFUs recovered from blood 22 h post I.P. infection with GBS strains. Significance was determined using Tukey’s Multiple Comparisons Test (*⁣*⁣**p < 0.0001). (F) Bacterial CFUs recovered from spleen 22 h post I.P. infection with GBS strains. (G) Bacterial CFUs recovered from brains 22 h post I.P. infection with GBS strains. Significance was determined using Tukey’s Multiple Comparisons Test (∗p < 0.05).