TABLE 2.
Heart rate, blood pressure and anatomic variables.
| SHAM + SHAM + VEH (N = 8) | SHAM + SHAM + DMB (n = 8) | MI + STNx + VEH (n = 10) | MI + STNx + DMB (n = 9) | |
|---|---|---|---|---|
| Week 6 | ||||
| Heart rate (Beats/min) | 372 ± 15 | 380 ± 20 | 378 ± 13 | 391 ± 22 |
| Blood pressure (mmHg) | 132 ± 11 | 125 ± 13 | 147 ± 18 | 154 ± 15 |
| Week 14 | ||||
| Heart rate (Beats/min) | 386 ± 25 | 377 ± 19 | 395 ± 23 | 387 ± 16 |
| Blood pressure (mmHg) | 138 ± 20 | 130 ± 19 | 155 ± 21 | 148 ± 27 |
| Body weight (g) | 429 ± 5 | 435 ± 9 | 372 ± 7* | 377 ± 5* |
| LV/tibial length (mg/cm) | 221 ± 4 | 230 ± 5 | 296 ± 10* | 261 ± 8*§ |
| RV/tibial length (mg/cm) | 48 ± 2 | 47 ± 2 | 93 ± 8* | 72 ± 5*§ |
| Lung/tibial length (mg/cm) | 325 ± 5 | 316 ± 6 | 857 ± 76* | 514 ± 38*§ |
LV: left ventricular; RV: right ventricular; MI: myocardial infarction; STNx: 5/6 subtotal nephrectomy; VEH: vehicle; DMB: 1.0% 3,3-Dimethyl-1-butanol (DMB, a TMAO inhibitor).
a
p < 0.05 vs SHAM + SHAM + VEH or SHAM + SHAM + DMB; §p < 0.05 vs MI + STNx.