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. 2021 Sep 27;29(6):582–595. doi: 10.4062/biomolther.2021.125

Table 5.

FA biomarker candidates in studies included in the systematic review of IBD

Author (year) IBD type Sample FA biomarker candidate Additional description
Manfredi et al. (2019) CD/UC Serum Eicosapentaenoic acid
Docosahexaenoic acid
Linoleic acid
Tridecylic acid
Caprylic acid
Behenic acid
Lignoceric acid
Arachidic acid
Tricosylic acid
Arachidonic acid
Icosadienoic acid
Nervonic acid
Paulinic acid
Suberic acid
Horta et al. (2021) Fatigue CD Plasma Leukotriene B4 FA biomarker candidates in the 50 most discriminant biomarkers.
15S-HpETE
16R-HETE
Guan et al. (2020) CD/UC Plasma 12,13S-EOT FA biomarker candidates in the 55 most discriminant biomarkers.
Arachidonic acid
Eicosapentaenoic acid
5,6-EpETrE
2-hydroxyglutaric acid
Docosahexaenoic acid
8,9-EpETrE
8R-HpODE
Nervonic acid
9,12,13-TriHOME
Palmitic acid
2E-decenoyl-CoA
9-heptadecylenic acid
Traumatic acid
20-HETE
Cis-9-palmitoleic acid
Bazarganipour et al. (2019) UC Plasma FA 16:0, FA 18:0, FA 18:1, FA 20:1, FA 20:4, FA 20:5, FA 22:3, FA 22:4, FA 22:5 Although lipidomic analysis was done by using both plasma and tissue samples, fatty acid subclass was revealed only in plasma samples.
Eicosapentaenoic acid
Docosahexaenoic acid
Jansson et al. (2009) CD Feces Oleic acid
Stearic acid
Palmitic acid
Arachidonic acid
Octadecatrienoic acid
Linoleic acid
Prostaglandin F2α
2,3-dinor-8-iso-prostaglandin F2α
Prostaglandin F1α
Prostaglandin E2α
Murgia et al. (2018) CD Plasma FA 16:0, FA 16:1, FA 18:0, FA 18:1, FA 18:2, FA 22:1, FA 24:2, FA 24:3
Bene et al. (2006) UC Plasma Propionylcarnitine
Butyrylcarnitine
Isovalerylcarnitine
Octenoylcarnitine
Decanoylcarnitine
Myristoleylcarnitine
Palmitoylcarnitine
Oleylcarnitine
Hydroxyoleylcarnitine
Pearl et al. (2014) UC Tissue Linoleic acid
α-Linolenic acid
Arachidonic acid
Eicosapentaenoic acid
Docosahexaenoic acid
Docosapentaenoic acid
Scoville et al. (2018) CD Serum Not specifically mentioned Long chain, polyunsaturated, branched chain, and monohydroxy fatty acids are the FA biomarker candidates.
Tefas et al. (2020) CD Serum Linoleamide
Palmitorylamide
Palmitoleamide
Branched fatty acid esters of hydroxy fatty acids
Stearyl palmitoleate, Palmitoleyl stearate, Oleyl palmitate
Masoodi et al. (2013) UC Tissue 5-HETE
15-HETE
Prostaglandin E2
Prostaglandin D2
Thromboxane B2
Lai et al. (2019) CD Serum Docosahexaenoic acid
Linolenic acid
Arachidonic acid
Pelargonic acid
Propionylcarnitine
Butyrylcarnitine
Isovalerylcarnitine
Heptanoylcarnitine