FIGURE 3.

Mitochondrial Ca²⁺ Uniporter upregulation enhances the genesis of DADs through Ca²⁺- dependent opening of mPTP. (A) Dependence of the DAD amplitude on α_MCU and α_mPTP. (B) Time traces of V, ${\overline{\left[C{a}^{2+}\right]}}_i$, and ${\overline{\left[C{a}^{2+}\right]}}_m$ for the (α_mPTP, α_MCU) coordinates as marked in panel (A), following the same color codes. The zoomed-in sections of DAD and spontaneous Ca²⁺ oscillation are shown in the corresponding insets.