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. 2021 Oct 6;2(11):100235. doi: 10.1016/j.jtocrr.2021.100235

Figure 1.

Figure 1

Chest plain enhanced CT images and histopathological analysis of CT-guided biopsy specimen. (A) Transverse chest CT images depict lung mass and parenchymal emphysema. (B) Transverse and sagittal enhanced CT images reveal tumor invasion into vertebrae and ribs. (C) Coronal CT image suggests pleural dissemination (yellow arrowheads). (D) Immunohistopathologic analysis of the biopsy specimen. HE staining presents undifferentiated round to plasmacytoid cells with prominent nucleoli and overall monomorphism. Immunohistochemical features indicate the complete loss of SMARCA4 and SMARCA2 in tumor cells with retained expression in normal inflammatory and stromal cells, lack of TTF-1, p40, and Claudin-4. The PD-L1 TPS using the 22C3 pharmDx assay is 0%. COSMIC, Catalogue Of Somatic Mutations In Cancer; CT, computed tomography; HE, hematoxylin and eosin; PD-L1, programmed death ligand-1; TPS, tumor proportion score.