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FGF signaling pathways. (A) Binding of canonical FGFs to FGFR with HS/HSPG as a cofactor induces the formation of ternary FGF-FGFR-HS complex. The activated receptor is coupled to intracellular signaling pathways including the RAS-MAPK, PI3K-AKT, PLCν, and STAT pathways. (B) Binding of endocrine FGF to FGFR with Klotho as a cofactor induces the formation of ternary FGF-FGFR-Klotho complex.
