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. 2021 Oct 14;12:729851. doi: 10.3389/fimmu.2021.729851

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Copyright © 2021 Wirchnianski, Wec, Nyakatura, Herbert, Slough, Kuehne, Mittler, Jangra, Teruya, Dye, Lai and Chandran

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NPC2- and IGF2-tagged bsAbs afford pan-filovirus entry inhibition. (A) Heat map showing neutralizing IC₅₀ values for parental mAbs and NPC2- and IGF2-tagged bsAbs against all rVSVs bearing filovirus glycoproteins. IC₅₀ values were calculated from neutralization curves from 4–6 replicates from 2–3 independent experiments. For curves that did not cross the 50% threshold, IC₅₀ values were considered >100 nM. EBOV, Ebola virus; TAFV, Tai Forest virus; BDBV, Bundibugyo virus; BOMV, Bombali virus; SUDV, Sudan virus; RESTV, Reston virus; LLOV, Lloviu virus; MLAV, Mengla virus; MARV, Marburg virus. (B, C) Neutralization of authentic (B) EBOV and (C) MARV by parental mAbs and NPC2- and IGF2-tagged bsAbs. Means ± SD are shown for 2–4 replicates from 1–2 independent experiments.