Table 10.

Asymmetric aza-Michael addition for the formation of (S)-(−)-pyrazoline.

49	Ar1	Ar2	Yield [%]	ee [%]
a	Ph	Ph	77	92 (−)
b	Ph	4-MeOC6H4	71	90 (−)
c	Ph	4-FC6H4	72	90 (−)
d	Ph	4-FC6H4	62	92 (−)
e	Ph	2-MeOC6H4	89	92 (−)
f	Ph	2-MeOC6H4	52	94 (−)
g	Ph	2-thienyl	66	87 (−)
h	Ph	2-thienyl	60	91 (−)
i	Ph	3,4-(Cl)2C6H3	40 (62)a	92 (−)
j	4-MeOC6H4	Ph	60	89 (+)
k	4-ClC6H4	Ph	70	88 (−)
l	2-MeC6H4	Ph	62	89 (−)
m	3-MeOC6H4	Ph	61	91 (−)
n	2-thienyl	Ph	46	78 (−)

^aYield determined by NMR analysis of the crude reaction mixture using an internal standard.