Table 11.

Asymmetric aza-Michael addition reaction catalyzed by phase-transfer catalyst.

53	Conditionsa		R	Yield (%)		ee [%]
	A	B		A	B	A	B
a	A	B	Ph	91	90	90	93
b	A	B	4-Me-C6H4	93	90	90	91
c	A	B	4-BrC6H4	91	89	91	94
d	A	B	3-FC6H4	70	62	90	93
e	A	B	4-TBSOC6H4	94	92	92	95
f	A	B	2-naphthyl	85	70	90	91
g	A	B	2-thienyl	93	81	90	94
h	A	B	2-furyl	90	82	90	93
i	A	B	(CH3)2CHCH2	95	99	77	82
j	A	B	t-Bu	97	99	79	83

^aConditions A: cat. (0.05 mol %) at rt or 0 °C, conditions B: cat. (1 mol %) at 0 °C.