Table 15.

Enantioselective 1,6-aza-Michael addition of isoxazolin-5-ones to p-quinone methides.

67	R1	R2	Ar	Yield [%]	ee [%]a
a	Me	H	Ph	65	87
b	Et	H	Ph	51	81
c	Pr	H	Ph	50	81
d	Ph	H	Ph	77	54
e	Pr	H	Ph	78	89
f	Me	Me	Ph	66	62
g	Me	H	p-MeC6H4	62	88
h	Me	H	p-MeOC6H4	74	84
i	Me	H	p-ClC6H4	43	48
j	Me	H	p-O2NC6H4	47	89
k	Me	H	o-MeOC6H4	81	94
l	Me	H	o-ClC6H4	94	96
m	Me	H	o-BrC6H4	43	90
n	Me	H	m-MeOC6H4	20	25
o	Me	H	m-ClC6H4	36	81
p	Me	H	m-O2NC6H4	56	77
q	Pr	H	p-MeOC6H4	75	79
r	Pr	H	p-ClC6H4	78	88
s	Pr	H	p-O2NC6H4	80	86
t	Pr	H	o-ClC6H4	76	92
u	Pr	H	m-MeOC6H4	82	82
v	Pr	H	m-ClC6H4	80	88
w	Pr	H	Ph	71	86

^aDetermined by HPLC using a chiral stationary phase.