Table 16.

Asymmetric intermolecular aza-Michael addition of (E)-3-substituted-2-enoic acid.

71	R	Yield [%]	ee [%]
a	Me	75	97
b	Et	84	90
c	Pr	72	90
d	n-C5C11	76	88
e	n-C7C15	75	86
f	CH(CH3)2	57	76
g	CH2-OBn	89	85
h	(CH2)3-OBz	86	91
i	(CH2)2-SMe	78	87
j	(CH2)3-NHCbz	80	71
k	(CH2)2-C6H4-CF3-4	76	83
l	(CH2)2-C6H4-MeO-4	88	87
m	(CH2)2-C6H4-Br-2	85	88
n	(CH2)2-C6H3-3,4-(OMe)2	81	86
o	(CH2)2-2-naphthyl	90	87
p	(CH2)3-Ph	81	91
q	(CH2)4-Ph	84	88
r	CH2-Ph	80	71
s	Ph	0	–