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Asymmetric aza-Michael addition reaction for the synthesis of N-hydroxyaspartic acid derivatives catalyzed by chiral multifunctional thiourea/boronic acid.
| ||||
|
| ||||
| 76 | X | Yield [%] | ee [%] | dr |
|
| ||||
| a | t-BuO | 88 | 93 | – |
| b | BnO | 50 | 91 | – |
| c | EtO | 49 | 94 | – |
| d |
|
40 | – | 67:33 |
| e |
|
60 | – | 75:25 |
| f |
|
66 | 63 | – |
| g |
|
81 | 85 | 73:37 |
