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Intramolecular aza-Michael addition reaction catalyzed by chiral N-triflylphosphoramide.
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| 99 | R | Yield [%] | ee [%] |
|
| |||
| a | Ph | 95 | 97 (−) |
| b | 4-BrC6H4 | 90 | 58 (−) |
| c | 4-ClC6H4 | 90 | 67 (−) |
| d | 4-NO2C6H4 | 77 | 20 (−) |
| e | 4-MeC6H4 | 98 | 82 (−) |
| f | 4-MeOC6H4 | 94 | 60 (−) |
| g | 2-MeOC6H4 | 95 | 4 (+) |
| h | 1-naphthyl | 81 | 76 (+) |
| i | 2-naphthyl | 98 | 76 (−) |
