Table 26.

Asymmetric aza-Michael organocatalytic quadruple cascade reaction.

114	R1	R2	R3	Yield [%]	ee [%]a
a	Ph	Ph	Ph	63	97
b	Ph	Ph	4-MeOC6H4	51	89 (91)
c	Ph	Ph	4-ClC6H4	34	85 (95)
d	Ph	Ph	2,3-(OCH2O)C6H3	56	84 (87)
e	4-MeOC6H4	Ph	Ph	66	92 (91)
f	3-ClC6H4	Ph	Ph	69	91 (95)
g	4-O2NC6H4	Ph	Ph	58	95
h	Ph	4-MeC6H4	Ph	70	88
i	Ph	4-ClC6H4	Ph	71	95

^aValues in brackets correspond to the results obtained with the catalyst (R)-113.