Table 3.
Intramolecular enantioselective aza-Michael addition.
| |||||
|
| |||||
| 14 | X | n | PG | Yield [%] | ee [%]a |
|
| |||||
| a | O | 2 | Boc | 97 | 97 |
| b | O | 1 | Boc | 96 | 94 |
| c b | S | 2 | Cbz | 55 | 95 |
| d | S | 1 | Cbz | 91 | 92 |
aDetermined by means of chiral-phase HPLC analysis. bReaction time = 4 days.
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