Table 5.

Diastereoselective synthesis of bridged 1,2,3,4-tetrahydroisoquinoline derivatives using modularly designed organocatalyst.

25	R1	R2	R3	Yield [%]	ee [%]	dr
a	C6H5	H	Et	90	>99	94:6
b	4-F-C6H4	H	Et	81	>99	97:3
c	4-Cl-C6H4	H	Et	90	99	92:8
d	4-Br-C6H4	H	Et	80	>99	90:10
e	4-NC-C6H4	H	Et	77	99	87:13
f	4-Me-C6H4	H	Et	76	99	97:3
g	4-MeO-C6H4	H	Et	79	97	96:4
h	3-Cl-C6H4	H	Et	72	>99	88:12
i a	2-F-C6H4	H	Et	–	–	–
j a	2-Cl-C6H4	H	Et	–	–	–
k	C6H5	F	Et	73	>99	90:10
l	C6H5	MeO	Et	74	99	91:9
m	Me	H	Et	56	92	86:14
n	C6H5	H	Bn	75	99	89:11
o	4-Br-C6H4	H	Bn	77	>99	93:7

^aFormation of a complex mixture was observed.