Table 3.

Synthesis of different B-ring-fused and C-ring-fused bile acid tetrazoles.^a

starting compoundb	product of Schmidt reaction	product of total deprotection

^aSynthesis of tetrazoles was performed according to previously optimized conditions on a 1 mmol scale with 6 equiv of TMSN₃ and 3 equiv of TMSOTf. For ketones, ACN was used as a solvent, while for enones, DCM was the reaction solvent. ^bCompound 12 was prepared according to a literature procedure [41].