Table 4.
Results of antiproliferative activity testing (IC50 values less than 10 μM are marked with an asterisk, while a dash denotes an IC50 value higher than 100 μM).
compound | IC50 (μM), 72 h, MTT test | ||||||
| |||||||
MCF-7 | MDA-MB-231 | PC-3 | HeLa | HT-29 | A549 | MRC-5 | |
| |||||||
3 | — | 1.06* | 78.55 | 8.68* | — | — | N/Aa |
4 | 14.42 | 70.64 | 9.60* | — | — | 17.73 | N/A |
7 | — | 9.18* | — | — | — | — | — |
8 | — | — | 43.11 | — | — | 4.25* | N/A |
11 | — | 96.31 | 26.29 | 18.16 | — | — | N/A |
12 | — | 82.42 | 11.19 | 43.71 | — | 36.57 | — |
13 | — | — | — | 69.61 | 16.39 | — | — |
14 | — | — | — | 6.97* | 24.07 | — | — |
15 | — | — | — | 21.65 | 23.59 | — | N/A |
16 | — | 98.90 | 33.90 | 43.04 | 68.07 | — | — |
17 | — | — | — | 95.91 | — | 19.56 | — |
18 | 22.92 | 22.46 | 82.60 | 19.48 | 27.15 | 79.75 | — |
19 | — | 14.79 | — | 12.07 | 34.35 | — | N/A |
20 | N/A | 87.47 | — | — | 61.74 | — | — |
21 | 37.24 | 21.67 | — | 9.31* | 98.50 | — | N/A |
22 | — | 45.57 | — | — | 6.06* | — | — |
23 | — | 7.60* | 11.44 | — | — | — | N/A |
24 | — | 5.18* | 12.26 | 77.61 | — | — | — |
DOX [53] | 0.20* | 0.09* | 84.23 | 0.07* | 0.15* | 4.91* | 0.10* |
aIC50 value not available due to nonlinear dose dependence or hormetic effect.