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. 2021 Oct 14;12:760674. doi: 10.3389/fphar.2021.760674

FIGURE 10.

FIGURE 10

(A) Photomicrographs i–iv. The effects of Melissa officinalis L. essential oil (MO) on CA1 or CA3 neurons in the hippocampus of rats. (i) Normal Saline control showing high power view with neuronal cell nuclei and neural processes (Magnification ×400); (ii) Kindled rats treated with PTZ only (Magnification ×400); (iii) Rats treated with PTZ and 50 mg/kg of MO showing partial restoration of nuclei and neural fibrillary processes (Magnification ×400); (iv) Rats treated with PTZ and 100 mg/kg MO showing near total restoration of nuclei with their fibrillary neural processes (Magnification ×400); (B) Effects of Melissa officinalis L. essential oil (MO) on number of neurons in CA1 and CA3 in the hippocampus of rats In control animals (sal) in comparison to pentylenetetrazole-kindled mice pretreated with saline (sal) or MO. (i and ii) CA1 Non-kindled and CA1 Kindled, +++p < 0.001 (N/Saline vs PTZ), ***p < 0.001 (PTZ vs PTZ + MO 100 mg/kg); (iii and iv) CA3 Non-kindled and CA1 Kindled, +++p < 0.001 (N/Saline vs PTZ), **p < 0.01 (PTZ vs PTZ + MO 50 mg/kg), ***p < 0.001 (PTZ vs PTZ + MO 100 mg/kg). n = number of animals tested. Mean ± SEM.