TABLE 2.
Effects of Melissa officinalis L. essential oil (MO) on maximal electroshock (MES)-induced seizures in mice.
| Treatment (mg/kg) | No. Protected/No. of animal used | % Protection from tonic seizures | Protection from mortality | % Protection from mortality |
|---|---|---|---|---|
| N/Saline | 0/8 | 0.00 | 0/8 | 0.00 |
| MO (10) | 0/8 | 0.00 | 0/8 | 0,00 |
| MO (50) | 0/8 | 0.00 | 4/8 | 50 |
| MO (100) | 2/8 | 25 | 6/8 | 75 |
| MO (200) | 4/8 | 50 | 5/8 | 62.5 |
| Phenytoin (25) | 7/8 | 87.5 | 7/8 | 87.5 |
Data are presented as number of animals protected against maximal electroshock (MES)-induced seizures out of eight animals per group. Protection of animals against mortality also was investigated. The MES test was performed 30 min after systemic (i.p.) administration of the essential oil. The essential oil from Melissa officinalis (MO) was suspended in 0.5% Tween80 in physiological saline solution, which was also used as control. All solutions were administered intraperitoneally (ip) at a volume of 10 ml/kg body weight.