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. 2021 Oct 14;11:770428. doi: 10.3389/fonc.2021.770428

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Copyright © 2021 Feng, Zhang, Wang, Xie, Ji, Luo, Huang and Xia

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overview of HOX involvement in different tumors in human. The colors of HOX molecules indicate regulations in relevant tumor cell. The red font means the corresponding HOX genes is up-regulated in tumor, while the blue font means the corresponding HOX genes is down-regulated in comparison. Regulation of HOX factors in various tumor types described in this figure legend. [brain cancer mainly includes the glioma and neuroblastoma (4–11), lung cancer (12–24), hepatocellular carcinoma (25–31), bladder cancer (32, 33), cholangiocarcinoma (34), head and neck squamous cell carcinoma (35, 36), breast cancer (21–23, 37–54), gastric carcinoma and esophagus cancer (55–64), prostate cancer and renal carcinoma (43, 65–72), ovarian cancer (73–79), endometrial cancer and cervical cancer (80–84), leukemia (85–95), skin carcinoma (96–98)].