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. 2021 Oct 14;11:770428. doi: 10.3389/fonc.2021.770428

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Copyright © 2021 Feng, Zhang, Wang, Xie, Ji, Luo, Huang and Xia

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HOX genes in the hallmarks of cancer. The hallmarks of cancer comprise eight biological capabilities acquired during multistep development of human tumors. The hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic disease. They include acting as tumor suppressor, sustaining proliferative signaling, regulating epigenetic control, resisting in anti-cancer drugs, evading immune destruction, enabling ncRNA transcription, inducing angiogenesis, and promoting invasion and metastasis.