FIGURE 6.
In vivo NIR fluorescence imaging of tumor hypoxia in murine GBM39 tumor model via NO 2 ‐Rosol. (A) NIR fluorescence imaging of hypoxia in murine GBM39 tumor model via the smart probe (25 μM, 50 μL) undergoing bioreductive activation by upregulated NTR activity and subsequently imaged at select time points (λ ex = 503‐555 nm). (B) Quantitative analysis from corresponding tumor hypoxia imaging experiment. Bars are expressed as a TBR (n = 3). There are no statistically significant differences in the TBR between the time points using a one‐way analysis of variance followed by Tukey post hoc tests with the pre‐injection TBR serving as the control