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A schematic representation on the role of genetic modification of different cytokines/chemokines in activation of endogenous immune system in the context of CAR T cell therapy. Examples are based on the role of genetically modified CAR T cells (7x19 CAR T cells and IL-18 armored CAR T cells) in the activation of endogenous immune cells like CD8+ T cells, NK, NKT and DCs. CAF, Cancer Associated Fibroblasts.
