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. 2021 Oct 14;12:750815. doi: 10.3389/fphar.2021.750815

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Copyright © 2021 Wei, Zhan, Ding, Xu, Shi, Ren, Fang, Liu, Hou, Zhao, Li, Li, Li, Li, Lin, Yang, Xiao, Bai and Cao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dihydrotanshinone I reduces LPS-induced septic shock and inflammation in vivo. (A) Survival rate of septic shock in mice. After intraperitoneal injection of DHT (40 mg/kg) and LPS (20 mg/kg), the lethality of 6- to 8-week-old C57BL/6 female mice was monitored within 72 h (n = 10) (B–F) C57BL/6 female mice were given vehicle control, DHT (40 mg/kg), or MCC950 (40 mg/kg) for 1 h and then treated with LPS (20 mg/kg) for 4 h. Monocytes-macrophages (F4/80 + cells) (B), TNF-α (C), IL-1β (E) from serum and TNF-α (D), and IL-1β (F) in the peritoneal lavage fluid were measured using flow cytometry and ELISA. Data are represented as the mean ± SEM. Statistics differences were analyzed using an unpaired Student’s t-test *p < 0.05, **p < 0.01, ***p < 0.001, NS: not significant.