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. 2021 Oct 14;12:756825. doi: 10.3389/fimmu.2021.756825

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Copyright © 2021 Yang, Huang, Xu, Li, Wu, Dai, Ge, Yuan, Cao, Yang, Wu and Deng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Decreased miR-4512 expression in monocytes and macrophages contributes to a pro-inflammatory state. (A–C) Relative expression of miR-4512 (A), CXCL2 (B), and TLR4 (C) in PBMC, monocytes, and neutrophils isolated from SLE patients and control subjects, as determined by RT-qPCR. Data are presented as the mean ± SEM. ***P < 0.001; **P < 0.01; *P < 0.05; NS, not significant. (D–E) Concentrations of Th1 (including IL-1β, IL-12, TNF-α, and IFN-γ), Th2 (including IL-4, IL-6, and IL-10), and Th17 (IL-17) cytokines in the supernatants obtained from monocytes and macrophages transfected with NC/miR-4512-agomir/antagomir (D) or in the serum from SLE patients and control subjects (E), as determined by ELISA.