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. 2021 Oct 14;12:719954. doi: 10.3389/fimmu.2021.719954

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Copyright © 2021 Hann, Oo and Perera

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mechanisms by which Regulatory T cells (Tregs) suppress the immune response. Demonstration of both the direct and indirect mechanisms of Tregs. ^aLAG-3 involvement most characteristic of T-regulatory type 1 cells. DC, Dendritic cell; LAG-3, Lymphocyte activation gene 3; IDO, Indolamine-2,3-dioxygenase.