TABLE 3.
Longitudinal associations of blood UA levels with the risk of MCI.
| Blood UA (μmol/La) | Model 1 | Model 2 | Model 3 |
| HR (95% CI) | HR (95% CI) | HR (95% CI) | |
| Cox proportional hazards model | |||
| Per 10 μmol/L increment | 0.99 (0.98, 0.10) | 0.99 (0.98, 1.00) | 0.99 (0.97, 0.10) |
| Q1 | Ref. | Ref. | Ref. |
| Q2 | 0.84 (0.66, 1.06) | 0.84 (0.66, 1.07) | 0.82 (0.64, 1.06) |
| Q3 | 0.81 (0.64, 1.04) | 0.83 (0.65, 1.06) | 0.73 (0.56, 0.95) |
| Q4 | 0.74 (0.57, 0.96) | 0.75 (0.57, 0.98) | 0.73 (0.55, 0.96) |
| P for trend | 0.022 | 0.036 | 0.013 |
| Fine and Gray competing risks model b | |||
| Per 10 μmol/L increment | 0.98 (0.97, 0.99) | 0.98 (0.97, 0.99) | 0.98 (0.97, 0.99) |
| Q1 | Ref. | Ref. | Ref. |
| Q2 | 0.90 (0.71, 1.14) | 0.89 (0.69, 1.14) | 0.88 (0.68, 1.13) |
| Q3 | 0.89 (0.70, 1.13) | 0.80 (0.62, 1.04) | 0.79 (0.61, 1.02) |
| Q4 | 0.70 (0.54, 0.91) | 0.67 (0.51, 0.88) | 0.67 (0.51, 0.88) |
| P for trend | 0.014 | 0.018 | 0.003 |
UA, uric acid; HR, hazard, ratio; CI, confidence interval.
Model 1 adjusted for age, sex, and education; model 2 additionally adjusted for drinking, smoking, marital status, regular exercise, body mass index, central obesity, adequate medical service; model3 additionally adjusted for hypertension, diabetes mellitus, self-reported history of heart disease, and stroke and cardiovascular disease.
aThe cutoff values were 213.9, 265.0, and 320.9 μmol/L for women, and 252.0, 305.6, and 365.1 μmol/L for men.
bAdjusted for death as competing risk.