Table 2.
Differentially expressed placental metabolites among pregnant women with ICP and healthy pregnant women.
| Metabolites | VIP | Fold change (P:C) | P-value | Change in expression level |
|---|---|---|---|---|
| Glyceraldehyde | 1.60 | 1.56 | 1.05E-02 | UP |
| L-Proline | 1.48 | 1.78 | 2.47E-02 | UP |
| Glycocholic acid | 1.69 | 80.72 | 0.43E-02 | UP |
| L-Palmitoylcarnitine | 1.58 | 2.71 | 0.65E-02 | UP |
| D-Glucuronic acid | 1.44 | 0.17 | 3.25E-02 | DOWN |
| Thyroxine | 1.33 | 0.20 | 1.71E-02 | DOWN |
| Xanthurenic acid | 1.36 | 0.31 | 1.14E-02 | DOWN |
| Levulinic acid | 1.27 | 0.25 | 4.35E-02 | DOWN |
| N-Oleoylethanolamine | 1.20 | 0.32 | 4.82E-02 | DOWN |
Potential biomarkers were extracted based on variable important for the projection (VIP) >1. Table contains data for metabolites that were ≥1.5-fold upregulated or ≤0.67-fold downregulated in pregnant women with ICP (P) compared to healthy pregnant women (C). The P : C ratios are shown. The key metabolites data are bolded.