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. Author manuscript; available in PMC: 2021 Oct 28.
Published in final edited form as: Ann Neurol. 2020 Jul 9;88(2):348–362. doi: 10.1002/ana.25809

Figure 5. Biophysical properties of Na+ channels containing wild-type and variant Nav1.3 subunits.

Figure 5

(A) Slowly-inactivating (“persistent”) Na+ current quantified as a percentage of peak transient current during a voltage step from −120 to −10 mV. (B) Peak inward transient Na+ current recorded with current steps from −120 to +40 mV in 5 mV increments. (C) Voltage dependence of channel activation defined as the V1/2 of the Boltzman fit to the relationship of normalized conductance and voltage. (D) Time constant (τ) of fast inactivation, calculated for a voltage step from −120 to −10 mV. * p < 0.05; ** p < 0.01; *** p < 0.001; via one-way ANOVA with post-hoc correction for multiple comparisons with Bonferroni test. † p < 0.05 via one-way ANOVA without post-hoc correction.