Table 2.

Biophysical properties of wild-type and variant Nav1.3 channels.

	Peak current density	Voltage dependence of channel activation		Voltage dependence of inactivation		Persistent current	Inactivation tau	n
	pA/pF	V 1/2	k	V 1/2	k	% of peak	ms
Wild-type	511 ± 35	−27.4 ± 0.8	4.5 ± 0.2	−66.2 ± 0.9	7.2 ± 0.3	1.0 ± 0.1	0.52 ± 0.02	42
L855P	436 ± 51	−49.1 ± 1.0***	5.7 ± 0.3	−71.9 ± 1.6	4.9 ± 0.2	4.1 ± 0.6†	0.81 ± 0.06	21
I875T	460 ± 38	−35.1 ± 0.9***	4.9 ± 0.3	−63.9 ± 1.6	9.9 ± 0.9	10.9 ± 1.6***	0.83 ± 0.14	25
P1333L	447 ± 27	−38.3 ± 2.0***	4.9 ± 0.5	−66.0 ± 8.2	10.6 ± 1.4	10.2 ± 1.5*	0.82 ± 0.12	15
I1468R	265 ± 20***	−29.0 ± 1.4	6.5 ± 0.2	−41.2 ± 1.8***	16.0 ± 0.9	28.8 ± 1.8***	1.53 ± 0.13***	25
T1486I	569 ± 47	−31.2 ± 1.1	3.8 ± 0.2	−56.5 ± 2.2***	7.8 ± 0.5	14.8 ± 1.0***	1.93 ± 0.09***	36
K1506Nfs*18	15 ± 2***							24
R1621G	603 ± 43	−35.0 ± 1.0***	3.9 ± 0.2	−66.2 ± 2.2	11.4 ± 0.4	8.3 ± 1.4*	1.92 ± 0.13***	37
R1621Q	491 ± 41	−32.5 ± 1.2*	4.6 ± 0.2	−64.9 ± 1.3	9.1 ± 0.3	3.4 ± 0.6†	1.69 ± 0.10***	31
F1646C	482 ± 29	−29.6 ± 0.7	4.4 ± 0.2	−54.6 ± 0.9***	7.5 ± 0.6	3.8 ± 0.5†	0.80 ± 0.05	39
Y1669C	64 ± 11***							20
M1765I	657 ± 62	−40.3± 1.0***	4.2 ± 0.3	−71.7 ± 1.3	8.3 ± 0.8	2.3 ± 0.3†	0.66 ± 0.02	24
V1769A	363 ± 18	−30.1 ± 1.2	5.5 ± 0.3	−51.4 ± 3.4***	16.6 ± 1.8	32.3 ± 2.6***	1.39 ± 0.11***	27
V1280I	649 ± 53	−31.6 ± 1.2	4.3 ± 0.2	−70.5 ± 0.9	7.1 ± 0.3	1.4 ± 0.3	0.56 ± 0.03	25

^*p < 0.05

^**p < 0.01

^***p < 0.001; via one-way ANOVA with post-hoc correction for multiple comparisons with Bonferroni test

^†p < 0.0001 via unpaired two-tailed Student's t-test; not significant via one-way ANOVA with post-hoc correction