FIGURE 6.

In this figure, we compare predictions generated using the MLP Cytokine Trajectory Prediction/MLP Oxygen-Deficit Regressor with a set of stochastic replicates generated by the simulation. In panel (A), we contrast the future health-trajectory probability cones with networks that used data collected in the first 24 h (shaded in red) and networks that excluded the first-day data (shaded in blue); we note that the blue area appears purple as it is entirely contained within the red area. In panel (B), we present 100 stochastic replicates of the actual simulation health-trajectory, reseeded at the time of the first prediction (red) compared with the predicted probability cone trajectories (blue). In panel (C), we generated the simulation trajectory cone through reseeding the simulation’s random number generator at the upper and lower boundaries of the trajectory cone every 100 time steps from t = 1100 to t = 1800.