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. 2021 Oct 11;12:661217. doi: 10.3389/fphar.2021.661217

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Copyright © 2021 Hassan, Elebeedy, Matar, Fahmy Mohamed Elsayed and Abd El Maksoud.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histopathology pattern of wound healing after treatment with ZnO nanorods (ZnO-NRs), phenytoin compared with control (non-treated). (A) Negative control (non-treated) after 3 days. (B) Wound healing after treatment with 10 μg/ml of ZnO nanorods (ZnO-NRs) after 3 days. (C) Wound healing after treatment with 20 μg/ml of ZnO nanorods (ZnO-NRs) after 3 days. (D) Wound healing after treatment with phenytoin as positive control after 3 days. (E) Negative control (non-treated) after 5 days. (F) Wound healing after treatment with 10 μg/ml of ZnO nanorods (ZnO-NRs) after 5 days. (G) Wound healing after treatment with 20 μg/ml of ZnO nanorods (ZnO-NRs) after 5 days. (H) Wound healing after treatment with phenytoin as positive control after 5 days. (I) Negative control (non-treated) after 7 days. (J) Wound healing after treatment with 10 μg/ml of ZnO nanorods (ZnO-NRs) after 7 days. (K) Wound healing after treatment with 20 μg/ml of ZnO nanorods (ZnO-NRs) after 7 days. (L) Wound healing after treatment with phenytoin as positive control after 7 days. (M) Negative control (non-treated) after 10 days. (N) Wound healing after treatment with 10 μg/ml of ZnO nanorods (ZnO-NRs) after 10 days. (O) Wound healing after treatment with 20 μg/ml of ZnO nanorods (ZnO-NRs) after 10 days. (P) Wound healing after treatment with phenytoin as positive control after 10 days. (Q) Negative control (non-treated) after 14 days. (R) Wound healing after treatment with 10 μg/ml of ZnO nanorods (ZnO-NRs) after 14 days. (S) Wound healing after treatment with 20 μg/ml of ZnO nanorods (ZnO-NRs) after 14 days. (T) Wound healing after treatment with phenytoin as positive control after 14 days.