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. Author manuscript; available in PMC: 2022 May 28.
Published in final edited form as: Nanoscale. 2021 May 13;13(20):9252–9263. doi: 10.1039/d0nr08166c

Figure 6.

Figure 6.

Radiosensitizing effects, tested in H1299 cells with Gd@Cdots (30 μg/mL). (a) Lipid peroxidation, measured by Image-iT BODIPY assay. A decrease of 590/510 nm fluorescence ratio indicates an increased level of lipid peroxidation. *, p < 0.05. (b) DNA damage, measured by rH2AX staining. The images were acquired on an ImageStream X Mark II Imaging Flow Cytometer. (c) Clonogenic assay results. H1299 cells treated with Gd@Cdots (30 μg/mL) or PBS only and received 0–10 Gy radiation. The results were fit into an linear-quadratic equation: S(D)/S(0) = exp-(aD+bD2), where S is cell Survival fraction, D is radiation dose, and a&b are coefficients. (d) Radiation enhancement factor at 4 Gy (REF4), computed based on results from (c).